2-苯基-1H-喹啉-4-酮合成路线 （共 53 条）
反应条件
polyphosphoric acid
T=90 - 100°C; 6 h;
参考文献
REDDY US THERAPEUTICS, INC.; PAL, Manojit; KHANNA, Ish; SUBRAMANIAN, Venkataraman; PADAKANTI, Srinivas; PILLARISETTI, Sivaram
Patent: WO2006/58201 A2, 2006 ;
Location in patent: Page/Page column 121-122 ;
反应条件
in diphenylether
T=240 - 250°C; 0.166667 h; Yield given;
参考文献
Kuo; Lee; Juang; Lin; Wu; Chang; Lednicer; Paull; Hamel
Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1146 - 1156
反应条件
diethylamine; bis-triphenylphosphine-palladium(II) chloride
T=120°C; 6 h; Pressure (range begins): 20 <unit not given>;
参考文献
Torii, Sigeru; Okumoto, Hiroshi; Xu, Long He; Sadakane, Masahiro; Shostakovsky, Michel V.; Ponomaryov, Andrew B.; Kalinin, Valery N.
Tetrahedron, 1993 , vol. 49, # 31 p. 6773 - 6784
反应条件
palladium on activated charcoal; copper(l) iodide; triphenylphosphine in triethylamine; N,N-dimethyl-formamide
T=75 - 80°C; 3 h;
参考文献
Venkataraman, Subramanian; Barange, Deepak Kumar; Pal, Manojit
Tetrahedron Letters, 2006 , vol. 47, # 41 p. 7317 - 7322
反应条件
palladium on activated charcoal; copper(l) iodide; triphenylphosphine in triethylamine; N,N-dimethyl-formamide
T=75 - 80°C; 3 h;
参考文献
Venkataraman, Subramanian; Barange, Deepak Kumar; Pal, Manojit
Tetrahedron Letters, 2006 , vol. 47, # 41 p. 7317 - 7322
反应条件
palladium on activated charcoal; copper(l) iodide; triphenylphosphine in triethylamine; N,N-dimethyl-formamide
T=75 - 80°C; 3 h;
参考文献
Venkataraman, Subramanian; Barange, Deepak Kumar; Pal, Manojit
Tetrahedron Letters, 2006 , vol. 47, # 41 p. 7317 - 7322
反应条件
diethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride
T=120°C; P=15200 Torr; 1 h; Yield given;
参考文献
Kalinin; Shostakovsky; Ponomaryov
Tetrahedron Letters, 1992 , vol. 33, # 3 p. 373 - 376
反应条件
tri-ruthenium(0)dodecacarbonyl; carbon monoxide; DIAN-Me in ethanol; water
T=170°C; P=22800 Torr; 3 h; Title compound not separated from byproducts;
参考文献
Tollari, Stefano; Cenini, Sergio; Ragaini, Fabio; Cassar, Lucia
Journal of the Chemical Society, Chemical Communications, 1994 , # 15 p. 1741 - 1742
反应条件
1: 59 percent / ethanol. NaOH / 8 h / 5 °C
2: 72 percent / pyridine
3: 70 percent / Br2 / CCl4
4: 60 percent / aq. HCl / ethanol / 1 h / Heating
5: 1) aq. KOH / 1) EtOH, 2) pyridine, 6h
View Scheme
参考文献
Donnelly, John A.; Farrell, David F.
Journal of Organic Chemistry, 1990 , vol. 55, # 6 p. 1757 - 1761
反应条件
1: 88 percent / CuI; K2CO3; N,N'-dimethylethylenediamine / molecular sieves 5 Angstroem / toluene / 24 h / 90 °C
2: 96 percent / NaOH / dioxane / 1 h / 110 °C
View Scheme
参考文献
Jones, Carrie P.; Anderson, Kevin W.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2007 , vol. 72, # 21 p. 7968 - 7973
