6-溴-1H-咪唑并[4,5-B]吡啶-2(3H)-酮合成路线 (共 7 条)
反应条件
in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; GLICK, Gary D.; TAYLOR, Clarke, Bentley; TOOGOOD, Peter, Laurence; VAN HUIS, Chad, Alan
Patent: WO2010/121164 A2, 2010 ;
Location in patent: Page/Page column 61 ;
反应条件
in N,N-dimethyl-formamide T=100°C; 16 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; LLOYD, John; FINLAY, Heather; JIANG, Ji; NEELS, James; DHONDI, Naveen Kumar; GUNAGA, Prashantha; BANERJEE, Abhisek; ADISECHAN, Ashokkumar
Patent: WO2011/28741 A1, 2011 ;
Location in patent: Page/Page column 284-285 ;
WO 2011/028741 A1
反应条件
in chloroform 12 h; Heating / reflux;
参考文献
WO2004/35549 A1, ;
Page 200 ;
WO 2004/035549 A1
反应条件
bromine in acetic acid 5 h; Heating;
参考文献
Yutilov; Lopatinskaya; Smolyar; Korol'
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 2 p. 280 - 281
反应条件
1: potassium carbonate / acetonitrile 2: 4-(N,N-dimethlyamino)pyridine View Scheme
参考文献
UNIVERSITY OF ROCHESTER; GELBARD, Harris, A.; DEWHURST, Stephen; GOODFELLOW, Val, S.; WIEMANN, Torsten; RAVULA, Satheesh, Babu; LOWETH, Colin, J.
Patent: WO2011/149950 A2, 2011 ;
WO 2011/149950 A2
反应条件
sodium acetate; chlorine in acetic acid Heating;
参考文献
Yutilov; Lopatinskaya; Smolyar; Gres'ko
Russian Journal of Organic Chemistry, 2005 , vol. 41, # 4 p. 575 - 579
反应条件
in trichlorophosphate
参考文献
NEUROGEN CORPORATION
Patent: US2003/36652 A1, 2003 ;
US 20030036652 A1