4-溴-2,6-二甲基苯甲醚合成路线 （共 24 条）
反应条件
1: platinum; ethanol / Hydrogenolyse 2: glacial acetic acid 3: platinum; ethanol / Hydrogenolyse View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. <5> 6, p. 1025,1033
反应条件
pyridine; copper(II) sulfate
参考文献
Bielig; Luetzel
Justus Liebigs Annalen der Chemie, 1957 , vol. 608, p. 140,156
反应条件
magnesium in tetrahydrofuran; pentane
参考文献
Chirotech Technology, Ltd.
Patent: US6156935 A1, 2000 ;
反应条件
1: With magnesium in tetrahydrofuran T=20°C; Grignard reaction; 2 h; 2: With N,N-diethylphosphoramidous dichloride in tetrahydrofuran T=0 - 50°C; phosphorylation; 3 h; 3: With hydrogenchloride in pentane T=0°C; Hydrolysis; 1 h;
参考文献
Derrien, Nadine; Dousson, Cyril B.; Roberts, Stanley M.; Berens, Ulrich; Burk, Mark J.; Ohff, Manuela
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3341 - 3352
反应条件
1: With iodine; magnesium in tetrahydrofuran T=0 - 20°C; 1 h; Inert atmosphere; 2: With phosphonic acid diethyl ester in tetrahydrofuran T=0 - 20°C; 12 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 22 p. 5197 - 5199
反应条件
in N,N-dimethyl-formamide T=136°C;
参考文献
ASTRAZENECA AB; BLID, Jan; GINMAN, Tobias; GRAVENFORS, Ylva; KARLSTROeM, Sofia; KOLMODIN, Karin; LINDSTROeM, Johan; PLOBECK, Niklas; RAHM, Fredrik; SWAHN, Britt-Marie; VIKLUND, Jenny; VON BERG, Stefan; VON KIESERITZKY, Fredrik
Patent: WO2011/2407 A1, 2011 ;
Location in patent: Page/Page column 74-75 ;
WO 2011/002407 A1
反应条件
in N,N-dimethyl-formamide T=180°C; Inert atmosphere;
参考文献
Zhang, Yu; Lu, Zhenjie; Desai, Aman; Wulff, William D.
Organic Letters, 2008 , vol. 10, # 23 p. 5429 - 5432
反应条件
diethyl ether; magnesium anschliessend mit CO2 behandeln;
参考文献
Baddeley et al.
Journal of the Chemical Society, 1956 , p. 2455,246
反应条件
sulfuric acid; nitric acid; acetic anhydride
参考文献
Bruice et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 83,87
反应条件
1: 63 percent / Mg / tetrahydrofuran 2: 63 percent / HSiCl3 / toluene View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 6 p. 735 - 738
