(3AR,4S,7R,7AS) 4,7-亚甲基-1H-异吲哚-1,3(2H)-二酮合成路线 （共 9 条）
反应条件
ammonium hydroxide in tetrahydrofuran T=190°C; 2 h;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
Title/Abstract Full Text View citing articles Show Details
Ishizumi; Kojima; Antoku; Saji; Yoshigi
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 12 p. 2139 - 2151
反应条件
1: With pyridine T=0 - 20°C; 2: With hydrogenchloride in water
参考文献
WO2013/14665 A1, ;
Page/Page column 19 ;
反应条件
1: 95.9 percent / H2 / 10percent Pd/C / H2O; tetrahydrofuran / 1.5 h / Ambient temperature 2: 80.5 percent / 7percent aq. NH3 / tetrahydrofuran / 2 h / 190 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 12 p. 2139 - 2151
反应条件
1.1: 1 h / 200 °C 2.1: palladium on activated charcoal; hydrogen / 25 - 35 °C / 3750.38 Torr / |Inert atmosphere; |Autoclave 3.1: tetrahydrofuran / 0.17 h / 25 - 35 °C 3.2: 0 - 35 °C View Scheme
反应条件
1: potassium carbonate / isopropyl alcohol / 4 h 2: potassium carbonate / anhydrous xylene / 40 h / |Reflux View Scheme
反应条件
1.1: potassium carbonate; dibenzo-18-crown-6 / anhydrous xylene / 3 h 2.1: methanol / 0.17 h / 60 - 65 °C 2.2: 1 h / 60 - 65 °C View Scheme
反应条件
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating 2: 81.3 percent / K2CO3, KI / dimethylformamide / 1 h / 90 °C View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
potassium carbonate; 18-crown-6 ether in xylene 6 h; Heating;
参考文献
Cybulski; Chilmonczyk; Szelejewski; Wojtasiewizc; Wrobel
Archiv der Pharmazie, 1992 , vol. 325, # 5 p. 313 - 315
反应条件
potassium carbonate; phenylmethyltriethylammonium bromide 1.) toluene, reflux, 4 h, 2.) reflux, 5 h; Yield given. Multistep reaction;
参考文献
Cybulski; Chilmonczyk; Szelejewski; Wojtasiewizc; Wrobel
Archiv der Pharmazie, 1992 , vol. 325, # 5 p. 313 - 315
