4-氯-2-(甲基硫代)嘧啶-5-甲醛合成路线 （共 4 条）
反应条件
manganese(IV) oxide in chloroform
参考文献
AMGEN INC.
Patent: WO2009/85185 A1, 2009 ;
Location in patent: Page/Page column 129 ;
WO 2009/085185 A1
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere 2: manganese(IV) oxide / chloroform / 20 - 40 °C View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-guo; DAI, Guangxiu; XIAO, Kun; JIA, Hong; ZHANG, Zhulin; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; CHAI, Wenying
Patent: WO2014/15830 A1, 2014 ;
反应条件
lithium diisopropyl amide 1) THF, -78 deg C, 1 h, 2) -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Ple; Turck; Martin; Barbey; Queguiner
Tetrahedron Letters, 1993 , vol. 34, # 10 p. 1605 - 1608
反应条件
N-ethyl-N,N-diisopropylamine; hydrazine in ethanol T=0 - 50°C; 2.08333 h;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2008/94575 A2, 2008 ;
Location in patent: Page/Page column 56-57 ;
WO 2008/094575 A2
