2,5-二甲氧基苯磺酰氯合成路线 （共 10 条）
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
phosphorus pentachloride
参考文献
Journal of Organic Chemistry, , vol. 30, p. 1520 - 1523
反应条件
1.1: 99 percent / Zn; aq. HCl 2.1: KOH / methanol / 1 h 2.2: 96 percent / methanol / 0.5 h / Heating View Scheme
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
参考文献
FMC Corporation
Patent: US4743291 A1, 1988 ;
反应条件
zinc in tetrahydrofuran; water
参考文献
Merck Patent Gesellschaft mit beschrankter Haftung
Patent: US3988468 A1, 1976 ;
反应条件
hydrogenchloride; zinc
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
1.1: 99 percent / Zn; aq. HCl
2.1: KOH / methanol / 1 h
2.2: 96 percent / methanol / 0.5 h / Heating
3.1: POCl3 / 40 - 50 °C
3.2: 86 percent / 0.25 h / 70 °C
View Scheme
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Dahl, Russell; Sergienko, Eduard A.; Su, Ying; Mostofi, Yalda S.; Yang, Li; Simao, Ana Maria; Narisawa, Sonoko; Brown, Brock; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Smith, Layton H.; O'Neill, W. Charles; Millan, Jose Luis; Cosford, Nicholas D. P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6919 - 6925
反应条件
1.1: 99 percent / Zn; aq. HCl
2.1: KOH / methanol / 1 h
2.2: 99 percent / methanol / 0.5 h / Heating
3.1: POCl3 / 40 - 50 °C
3.2: 73 percent / 0.25 h / 70 °C
View Scheme
参考文献
Jacob III; Anderson III; Meshul; Shulgin; Castagnoli Jr.
Journal of Medicinal Chemistry, 1977 , vol. 20, # 10 p. 1235 - 1239
反应条件
1.1: 99 percent / Zn; aq. HCl
2.1: KOH / methanol / 1 h
2.2: 99 percent / methanol / 0.5 h / Heating
3.1: POCl3 / 40 - 50 °C
3.2: 73 percent / 0.25 h / 70 °C
4.1: 73 percent / NH4OAc / Heating
View Scheme
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
