4-氨基-3-硝基-苯甲脒合成路线 （共 6 条）
反应条件
1: gas. HCl / dioxane / 0 - 5 °C 2: NH3 / ethanol / 6 h / Heating View Scheme
参考文献
Array Biopharma Inc.
Patent: US6221914 B1, 2001 ;
US 6221914 B1
反应条件
ammonia in ethanol 6 h; Heating; Yield given;
参考文献
Fairley; Tidwell; Donkor; Naiman; Ohemeng; Lombardy; Bentley; Cory
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1746 - 1753
反应条件
1: 94 percent / 35 - 45 °C 2: potassium nitrate, conc. H2SO4 / 3.5 h / 0 °C 3: 2 N H2SO4 / 3 h / Heating 4: gas. HCl / dioxane / 0 - 5 °C 5: NH3 / ethanol / 6 h / Heating View Scheme
参考文献
Fairley; Tidwell; Donkor; Naiman; Ohemeng; Lombardy; Bentley; Cory
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1746 - 1753
反应条件
1: potassium nitrate, conc. H2SO4 / 3.5 h / 0 °C 2: 2 N H2SO4 / 3 h / Heating 3: gas. HCl / dioxane / 0 - 5 °C 4: NH3 / ethanol / 6 h / Heating View Scheme
参考文献
Fairley; Tidwell; Donkor; Naiman; Ohemeng; Lombardy; Bentley; Cory
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1746 - 1753
反应条件
1: 2 N H2SO4 / 3 h / Heating 2: gas. HCl / dioxane / 0 - 5 °C 3: NH3 / ethanol / 6 h / Heating View Scheme
参考文献
Fairley; Tidwell; Donkor; Naiman; Ohemeng; Lombardy; Bentley; Cory
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1746 - 1753
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 12 p. 1746 - 1753
