5-氯-1-甲基-1H-吲哚-2-羧酸甲酯合成路线 （共 3 条）
反应条件
1: 5-chloro-1-methyl-indole-2-carboxylic acid With sodium hydride in 1,4-dioxane T=0°C; 0.25 h; 2: methyl iodide in 1,4-dioxane T=0 - 20°C; 49 h;
参考文献
DEVGEN N.V.
Patent: WO2006/66879 A2, 2006 ;
Location in patent: Page/Page column 48-49; 53 ;
WO 2006/066879 A2
反应条件
potassium hydroxide in acetone T=0 - 20°C;
参考文献
Li, Chang-Feng; Liu, Hiu; Liao, Jie; Cao, Yi-Ju; Liu, Xiao-Peng; Xiao, Wen-Jing
Organic Letters, 2007 , vol. 9, # 10 p. 1847 - 1850
反应条件
1: With sodium hydroxide; water in ethanol T=45°C; 0.5 h; 2: With hydrogenchloride in water T=0°C; pH=1;
参考文献
DEVGEN N.V.
Patent: WO2006/66879 A2, 2006 ;
Location in patent: Page/Page column 53; 48 ;
WO 2006/066879 A2
