1: ethanol / 1 h / Reflux 2: 1,2-dichloro-benzene / 5 h / Reflux View Scheme

1: With sodium methylate in methanol T=20°C; 12 h; 2: With sodium tetrahydroborate in methanol T=20 - 80°C; 3 h; 3: With potassium hydroxide in methanol; water

in water

1: 13 percent / BCl3, ZnCl2 / benzene / 0.5 h / Heating 2: 68 percent / NaBH4 / dioxane; H2O / 2 h / Heating View Scheme

1: 42 percent / N-bromosuccinimide, H2SO4 / tetrahydrofuran / 10 h / -78 °C 2: 85 percent / dioxane / 10 h / 105 °C 3: 68 percent / NaH / tetrahydrofuran; dimethylformamide / 3 h / 25 °C 4: 91 percent / Bu3SnH, AIBN / benzene / 3 h / 80 °C 5: 1.) ozone, 2.) NaBH4 / 1.) EtOH, -78 deg C, 3 min, 2.) EtOH, H2O, -78 to 24 deg C, 4 h 6: 89 percent / Et3N / CH2Cl2 / 0.42 h / 0 °C 7: 75 percent / H2 / 10percent Pd/C / tetrahydrofuran / 7 h / 24 °C / 760 Torr 8: 100 percent / HCl / ethyl acetate / 0.17 h / 24 °C 9: 71 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, K2CO3 / dimethylformamide / 20 h / 24 °C 10: 91 percent / NaH / tetrahydrofuran; dimethylformamide / 0.42 h / 24 °C View Scheme

1: 42 percent / N-bromosuccinimide, H2SO4 / tetrahydrofuran / 10 h / -78 °C 2: 85 percent / dioxane / 10 h / 105 °C 3: 68 percent / NaH / tetrahydrofuran; dimethylformamide / 3 h / 25 °C 4: 91 percent / Bu3SnH, AIBN / benzene / 3 h / 80 °C 5: 1.) ozone, 2.) NaBH4 / 1.) EtOH, -78 deg C, 3 min, 2.) EtOH, H2O, -78 to 24 deg C, 4 h 6: 89 percent / Et3N / CH2Cl2 / 0.42 h / 0 °C 7: 75 percent / H2 / 10percent Pd/C / tetrahydrofuran / 7 h / 24 °C / 760 Torr 8: 100 percent / HCl / ethyl acetate / 0.17 h / 24 °C 9: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, Et3N / dimethylformamide / 45 h / 24 °C 10: 90 percent / NaH / tetrahydrofuran / 0.42 h / 24 °C View Scheme

1: 2 h / Heating 2: 74 percent / diphenyl ether / 0.5 h / Heating View Scheme

暂无反应条件数据

in dichloromethane T=20°C;

1: 7 percent / BCl3, ZnCl2 / benzene / 0.5 h / Heating 2: 31 percent / NaBH4 / dioxane; H2O / 2 h / Heating View Scheme