2,3,4-三氟-6-硝基苯胺合成路线 （共 6 条）
反应条件
sulfuric acid; potassium nitrate Ambient temperature;
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
ammonia in tetrahydrofuran T=20°C; 16 h; Sealed tube;
参考文献
SCIFLUOR LIFE SCIENCES, LLC; Duggan, Mark E.; Furuya, Takeru; Edwards, D. Scott; Purohit, Ajay
Patent: US2013/287686 A1, 2013 ;
Location in patent: Paragraph 0148; 0149 ;
反应条件
1: aq. HCl / 90 °C 2: 10 percent / HNO3 / acetic acid / 4 h / 90 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 121, # 2 p. 171 - 175
反应条件
1: With tert.-butylnitrite in DMF (N,N-dimethyl-formamide) T=45 - 75°C; 2.25 - 4 h; 2: With hydrogenchloride in DMF (N,N-dimethyl-formamide); water
参考文献
DR. REDDY'S LABORATORIES LTD.
Patent: WO2004/37765 A1, 2004 ;
Location in patent: Page 7; 8-9 ;
反应条件
KNO3; sulfuric acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate
参考文献
State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon, Eugene Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California
Patent: US5631373 A1, 1997 ;
反应条件
tin(ll) chloride in ethanol; ethyl acetate
T=70°C; 0.583333 h;
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
