反应条件
1.1: 72 percent / NaOMe / methanol / 1.5 h / Heating
2.1: 96 percent / NaBH4 / methanol / 1 h / 20 °C
3.1: 100 percent / Me3SiBr / 0.17 h / 20 °C
4.1: LiHMDS / tetrahydrofuran / 1.25 h / -70 °C
4.2: 86 percent / tetrahydrofuran / 18 h / 0 °C
5.1: 94 percent / H2O2; LiOH / tetrahydrofuran; H2O / 3 h / 20 °C
6.1: NaBH4 / tetrahydrofuran / 0.75 h / 20 °C
6.2: 90 percent / I2 / tetrahydrofuran / 96 h / 20 °C
7.1: 97 percent / NBS; Ph3P / CH2Cl2 / 18 h / 20 °C
8.1: BuLi / hexane / 0.5 h / -75 °C
8.2: 91 percent / tetrahydrofuran / 20 h / -75 - -20 °C
9.1: 90 percent / 1N HCl / acetonitrile / 1.5 h / 20 °C
10.1: 82 percent / Et3N / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
