(4S)-叔丁基-2-[2-(二苯基膦基)苯基]-4,5-二氢噁唑合成路线 （共 14 条）
反应条件
1: bis-diphenylphosphine With copper(l) iodide; N-methyl-2-(methylamino)ethylamine in toluene T=20°C; 0.333333 h; Inert atmosphere; 2: 2-(2-bromophenyl)-4-(1,1-dimethylethyl)-4,5-dihydro-(4S)-oxazole With caesium carbonate in toluene T=110°C; 21 h; Inert atmosphereSealed vessel;
参考文献
Kraut, Michael R.; Mohr, Justin T.; Stoltz, Brian M.; Schumacher, Andreas; Pfaltz, Andreas
Organic Syntheses, 2009 , vol. 86, p. 181 - 193
反应条件
in tetrahydrofuran T=20°C; 18 h; Inert atmosphereSchlenk technique;
参考文献
Korte, Nicholas J.; Stepanova, Valeria A.; Smoliakova, Irina P.
Journal of Organometallic Chemistry, 2013 , vol. 745-746, p. 356 - 362
反应条件
1: 89.5 percent / Na2CO3 / CH2Cl2; H2O / 12 h / 20 °C 2: 81.2 percent / p-toluenesulfonyl chloride; triethylamine / CH2Cl2 / 22 h / 55 °C 3: 81 percent / copper(I) iodide; N,N'-dimethylethylenediamine; cesium carbonate / toluene / 6 h / 110 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 13 p. 2529 - 2531
反应条件
1: 89.5 percent / Na2CO3 / CH2Cl2; H2O / 12 h / 20 °C 2: 81.2 percent / p-toluenesulfonyl chloride; triethylamine / CH2Cl2 / 22 h / 55 °C 3: 81 percent / copper(I) iodide; N,N'-dimethylethylenediamine; cesium carbonate / toluene / 6 h / 110 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 13 p. 2529 - 2531
反应条件
1: 81.2 percent / p-toluenesulfonyl chloride; triethylamine / CH2Cl2 / 22 h / 55 °C 2: 81 percent / copper(I) iodide; N,N'-dimethylethylenediamine; cesium carbonate / toluene / 6 h / 110 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 13 p. 2529 - 2531
反应条件
in tetrahydrofuran Heating;
参考文献
Allen, Joanne V.; Dawson, Graham J.; Frost, Christopher G.; Williams, Jonathan M. J.; Coote, Steven J.
Tetrahedron, 1994 , vol. 50, # 3 p. 799 - 808
反应条件
1: 56 percent / ZnCl2 / chlorobenzene / 48 h / Heating 2: 92 percent / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 50, # 3 p. 799 - 808
反应条件
1: 99 percent / Et3N / dioxane / 1.5 h 2: 98 percent / Et3N, p-TsCl / CH2Cl2 / 24 h / Heating 3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane a) -20 deg C, 2 h, b) RT, overnight View Scheme
参考文献
Tetrahedron, , vol. 52, # 21 p. 7547 - 7583
反应条件
1: 98 percent / Et3N, p-TsCl / CH2Cl2 / 24 h / Heating 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane a) -20 deg C, 2 h, b) RT, overnight View Scheme
参考文献
Tetrahedron, , vol. 52, # 21 p. 7547 - 7583
反应条件
1: 34 percent / pyridine, PPh3, Et3N / CCl4; acetonitrile / 24 h 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane a) -20 deg C, 2 h, b) RT, overnight View Scheme
参考文献
Tetrahedron, , vol. 52, # 21 p. 7547 - 7583
