5-氯-3-苯基硫基-1H-吲哚-2-甲酰胺合成路线 （共 4 条）
反应条件
1.1: NaH / dimethylformamide / 0.25 h / 0 °C 1.2: 45 percent / dimethylformamide / 50 °C 2.1: 91 percent / CH2Cl2; methanol; hexane / 1.5 h / 20 °C 3.1: 51 percent / aq. NH3; NH4Cl / 100 °C View Scheme
参考文献
Williams; Ciccarone; MacTough; Rooney; Balani; Condra; Emini; Goldman; Greenlee; Kauffman; O'Brien; Sardana; Schleif; Theoharides; Anderson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1291 - 1294
反应条件
1.1: NaH / dimethylformamide / 0.25 h / 0 °C 1.2: 45 percent / dimethylformamide / 50 °C 2.1: 91 percent / CH2Cl2; methanol; hexane / 1.5 h / 20 °C 3.1: 51 percent / aq. NH3; NH4Cl / 100 °C View Scheme
参考文献
Williams; Ciccarone; MacTough; Rooney; Balani; Condra; Emini; Goldman; Greenlee; Kauffman; O'Brien; Sardana; Schleif; Theoharides; Anderson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1291 - 1294
反应条件
3-chloro-benzenecarboperoxoic acid in methanol; chloroform T=20°C; 6 h;
参考文献
Williams; Ciccarone; MacTough; Rooney; Balani; Condra; Emini; Goldman; Greenlee; Kauffman; O'Brien; Sardana; Schleif; Theoharides; Anderson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1291 - 1294
反应条件
sodium thiosulfate in hexane; chloroform
参考文献
Merck and Co., Inc.
Patent: US5527819 A1, 1996 ;
