4-碘-2-甲氧基苯甲酸甲酯合成路线 （共 7 条）
反应条件
thionyl chloride T=0 - 20°C; 18 h; Inert atmosphere;
参考文献
ABBOTT LABORATORIES; CUSACK, Kevin, P.; BREINLINGER, Eric, C.; FIX-STENZEL, Shannon, R.; STOFFEL, Robert, H.; WOLLER, Kevin, R.
Patent: WO2011/71570 A1, 2011 ;
Location in patent: Page/Page column 202 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=25°C; 2 h;
参考文献
Chowdhury, Morshed A.; Abdellatif, Khaled R.A.; Dong, Ying; Das, Dipankar; Yu, Gang; Velazquez, Carlos A.; Suresh, Mavanur R.; Knaus, Edward E.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6855 - 6861
反应条件
potassium iodide; sulfuric acid; iodine; sodium nitrite in water
反应条件
potassium carbonate in acetone T=60°C; 20 h; Inert atmosphere;
参考文献
Ueno, Yuichiro; Jose, Jiney; Loudet, Aurore; Perez-Bolivar, Cesar; Anzenbacher, Pavel; Burgess, Kevin
Journal of the American Chemical Society, 2011 , vol. 133, # 1 p. 51 - 55
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=-78 - 25°C; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 133, # 1 p. 51 - 55
反应条件
1: AlH3 / tetrahydrofuran / 1.) reflux, 25.5 h, 2.) RT, 91 h 2: pyridinium dichromate / CH2Cl2 / 51 h / Ambient temperature View Scheme
参考文献
Ueno, Yuichiro; Jose, Jiney; Loudet, Aurore; Perez-Bolivar, Cesar; Anzenbacher, Pavel; Burgess, Kevin
Journal of the American Chemical Society, 2011 , vol. 133, # 1 p. 51 - 55
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Wyeth
Patent: US2003/55047 A1, 2003 ;
US 20030055047 A1
