N-甲氧基-N-甲基甲基吡啶羧酰胺合成路线 （共 6 条）
反应条件
1: pyridine-2-carboxylic acid With 4-methyl-morpholine; isobutyl chloroformate in dichloromethane T=-15°C; 15 h; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane T=-15 - 20°C; 4.25 h;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/97750 A1, 2005 ;
Location in patent: Page/Page column 215 ;
WO 2005/097750 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C; 1.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19151 A1, 2005 ;
Location in patent: Page/Page column 252 ;
WO 2005/019151 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Zhou, Jun; Li, Bo; Qian, Zhen-Chao; Shi, Bing-Feng
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1038 - 1046
反应条件
triethylamine in dichloromethane T=-10°C;
参考文献
Gebert, Andreas; Barth, Max; Linden, Anthony; Widmer, Ulrich; Heimgartner, Heinz
Helvetica Chimica Acta, 2012 , vol. 95, # 5 p. 737 - 760
反应条件
1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 - 40 °C 2: triethylamine / dichloromethane / 0 - 20 °C View Scheme
参考文献
Zhou, Jun; Li, Bo; Qian, Zhen-Chao; Shi, Bing-Feng
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1038 - 1046
反应条件
1: in tetrahydrofuran T=-78 - 20°C; 2: With ammonium chloride in tetrahydrofuran
参考文献
AMGEN INC.
Patent: US2010/160280 A1, 2010 ;
Location in patent: Page/Page column 79 ;
