(1-甲基-1H-吲哚-2-基)-甲醇合成路线 （共 15 条）
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide 8 h; Ambient temperature;
参考文献
Frigerio, Marco; Santagostino, Marco; Sputore, Simona; Palmisano, Giovanni
Journal of Organic Chemistry, 1995 , vol. 60, # 22 p. 7272 - 7276
反应条件
1: 2-hydroxymethyl-1-methyl-1H-indole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.0333333 h;
2: With methanesulfonyl chloride; lithium bromide in tetrahydrofuran; hexane
T=0°C; 0.5 h;
3: NaCH(CO2Me)2 in tetrahydrofuran; hexane
T=20°C; 2 h;
参考文献
Liu, Cong; Han, Xiaoqing; Wang, Xiang; Widenhoefer, Ross A.
Journal of the American Chemical Society, 2004 , vol. 126, # 12 p. 3700 - 3701
反应条件
1: 2-hydroxymethyl-1-methyl-1H-indole With n-butyllithium; methanesulfonyl chloride; lithium bromide in tetrahydrofuran
Inert atmosphere;
2: sodium salt of dimethylmalonate Inert atmosphere;
参考文献
Huang, Haoxi; Peters, Rene
Angewandte Chemie - International Edition, 2009 , vol. 48, # 3 p. 604 - 606
反应条件
1: DMAP; Et3N / diethyl ether / 20 °C
2: 57 percent / dppe; sodium hydride / Pd(dba)2 / dimethylformamide / 48 h / 80 °C
View Scheme
参考文献
Primault, Gaelle; Legros, Jean-Yves; Fiaud, Jean-Claude
Journal of Organometallic Chemistry, 2003 , vol. 687, # 2 p. 353 - 364
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C; 22 h;
参考文献
Agnusdei, Marianna; Bandini, Marco; Melloni, Alfonso; Umani-Ronchi, Achille
Journal of Organic Chemistry, 2003 , vol. 68, # 18 p. 7126 - 7129
