1-(5-氨基-2-甲氧基苯基)-4-甲基哌嗪合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol 1 h;
参考文献
Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David
Patent: US2013/53372 A1, 2013 ;
Location in patent: Paragraph 0543; 0544 ;
反应条件
1: H2SO4; KNO3 2: hydrazine / Raney nickel / ethanol View Scheme
参考文献
CAMBRIDGE ENTERPRISE LIMITED; GLEN, Robert; HILEY, Robin; BELL, James; SPRING, David; KAPADNIS, Prashant, Bhimrao
Patent: WO2011/98776 A1, 2011 ;
WO 2011/098776 A1
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / 0 - 20 °C 1.2: 16 h / Reflux 2.1: sulfuric acid / 0.17 h 2.2: 0 - 20 °C 3.1: hydrogen / palladium 10 on activated carbon / methanol / 1 h View Scheme
参考文献
Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David
Patent: US2013/53372 A1, 2013 ;
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / 0 - 20 °C 1.2: 16 h / Reflux 2.1: sulfuric acid / 0.17 h 2.2: 0 - 20 °C 3.1: hydrogen / palladium 10 on activated carbon / methanol / 1 h View Scheme
参考文献
Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David
Patent: US2013/53372 A1, 2013 ;
反应条件
1: 20 percent / Na2CO3 / butan-1-ol 2: 1.) N2H4*H2O, 2.) NaNO2, HCl View Scheme
参考文献
Clitherow; Scopes; Skingle; Jordan; Feniuk; Campbell; Carter; Collington; Connor; Higgins; Beattie; Kelly; Mitchell; Oxford; Wadsworth; Tyers
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2253 - 2257
反应条件
1: 20 percent / Na2CO3 / butan-1-ol 2: 1.) N2H4*H2O, 2.) NaNO2, HCl View Scheme
参考文献
Clitherow; Scopes; Skingle; Jordan; Feniuk; Campbell; Carter; Collington; Connor; Higgins; Beattie; Kelly; Mitchell; Oxford; Wadsworth; Tyers
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2253 - 2257
反应条件
hydrogenchloride; hydrazine hydrate; sodium nitrite Yield given. Multistep reaction;
参考文献
Clitherow; Scopes; Skingle; Jordan; Feniuk; Campbell; Carter; Collington; Connor; Higgins; Beattie; Kelly; Mitchell; Oxford; Wadsworth; Tyers
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2253 - 2257
