1-甲基-4-(3-硝基苯基)哌嗪合成路线 （共 8 条）
反应条件
potassium carbonate in dimethyl sulfoxide T=90°C; 24 h;
参考文献
THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Patent: WO2005/7625 A2, 2005 ;
Location in patent: Page 62 ;
反应条件
formic acid Heating;
参考文献
Romanelli; Manetti; Scapecchi; Borea; Dei; Bartolini; Ghelardini; Gualtieri; Guandalini; Varani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3946 - 3955
反应条件
caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in N,N-dimethyl-formamide T=90°C;
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
Location in patent: Page/Page column 126-127 ;
WO 2012/059932 A1
反应条件
caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; palladium diacetate in toluene T=90°C; Hartwig-Buchwald amination;
参考文献
Nguyen Thi, Hanh Thuy; Lee, Chong-Yew; Teruya, Kenta; Ong, Wei-Yi; Doh-ura, Katsumi; Go, Mei-Lin
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6737 - 6746
参考文献
IRM LLC
Patent: US2005/124637 A1, 2005 ;
Location in patent: Page/Page column 12 ;
US 20050124637 A1
反应条件
sodium carbonate in butan-1-ol
参考文献
US5556969 A1, ;
US 5556969 A
反应条件
1: With hydrogenchloride; tin(ll) chloride in ethanol; water T=60°C; 1 h; 2: With sodium hydroxide in ethanol; water T=20°C;
参考文献
Park, Chul Min; Kim, So Young; Park, Woo Kyu; Choi, Jung Hwan; Seong, Churl Min
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5221 - 5224
反应条件
palladium in methanol; ethanol; dichloromethane
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5618812 A1, 1997 ;
