3-(4-甲基哌嗪-1-基)苯胺合成路线 （共 6 条）
反应条件
1: With hydrogenchloride; tin(ll) chloride in ethanol; water T=60°C; 1 h; 2: With sodium hydroxide in ethanol; water T=20°C;
参考文献
Park, Chul Min; Kim, So Young; Park, Woo Kyu; Choi, Jung Hwan; Seong, Churl Min
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5221 - 5224
反应条件
palladium in methanol; ethanol; dichloromethane
反应条件
1: 93 percent / K2CO3 / dimethylsulfoxide / 24 h / 90 °C 2: H2 / Pd/C / ethyl acetate; methanol / 8 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 26 p. 8261 - 8269
反应条件
1: 93 percent / K2CO3 / dimethylsulfoxide / 24 h / 90 °C 2: H2 / Pd/C / ethyl acetate; methanol / 8 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 26 p. 8261 - 8269
反应条件
1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / N,N-dimethyl-formamide / 90 °C 2: hydrogen / palladium on activated charcoal / methanol / 3 h View Scheme
参考文献
WO2012/59932 A1, ;
WO 2012/059932 A1
反应条件
1: 98 percent / HCO2H / Heating 2: 58 percent / SnCl2*2H2O; HCl / 24 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 23 p. 3946 - 3955
