4-溴-3-甲基苯甲酸甲酯合成路线 （共 30 条）
反应条件
sulfuric acid in methanol 14 h; Reflux;
参考文献
Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Kennedy-Smith, Joshua; Minatti, Ana Elena; Palmer, Wylie Solang; Silva, Tania; Wilhelm, Robert Stephen
Patent: US2011/71150 A1, 2011 ;
Location in patent: Page/Page column 33 ;
反应条件
sulfuric acid in methanol; dichloromethane
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 2.5 h;
参考文献
WAKAMOTO PHARMACEUTICAL CO., LTD.
Patent: WO2006/51851 A1, 2006 ;
Location in patent: Page/Page column 65 ;
反应条件
hydrogenchloride; copper(I) bromide; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 15 p. 4416 - 4420
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in dimethyl sulfoxide T=80°C; Suzuki-Miyaura cross-coupling;
参考文献
NORTHWESTERN UNIVERSITY; Grunder, Sergio; Whalley, Adam C.; Valente, Cory; Stoddart, J. Fraser
Patent: US2013/122297 A1, 2013 ;
Location in patent: Paragraph 0033; 0083 ;
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl-formamide T=80°C; 20 h;
参考文献
Zhu, Lei; Duquette, Jason; Zhang, Mingbao
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3729 - 3732
参考文献
Wyeth
Patent: US2002/198196 A1, 2002 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in dichloromethane; water 10 h; Heating / refluxIrradiation;
参考文献
GALDERMA RESEARCH and DEVELOPMENT
Patent: US2007/15931 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Priestley, Eldon Scott; Decicco, Carl P.; Hudyma, Thomas W.; Zheng, Xiaofan
Patent: US2003/134853 A1, 2003 ;
反应条件
1: With N-bromosuccinmide in tetrachloromethane 2 h; Heating / reflux; 2: With 2,2'-azo-bisisobutyronitrile in tetrachloromethane Heating / reflux;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2006/21418 A1, 2006 ;
Location in patent: Page/Page column 97 ;
WO 2006/021418 A1
