4-苯甲氧基苯(甲)酰氯合成路线 （共 47 条）
反应条件
1.1: pyridine / 15 h / 20 °C / Inert atmosphere
2.1: pyridine; potassium hydroxide / 3 h / 70 °C
2.2: Cooling with ice
3.1: sulfuric acid; acetic acid / 1.5 h / 80 °C
4.1: boron tribromide / dichloromethane / 1.5 h / 0 °C / Inert atmosphere
4.2: 0.5 h / 20 °C / Inert atmosphere
5.1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran; methanol / 1.5 h / 20 °C
View Scheme
参考文献
Soulage, Christophe O.; Grand, Lucie; Geloen, Alain; Chambert, Stephane
Tetrahedron Letters, 2012 , vol. 53, # 5 p. 480 - 483
反应条件
1: triethylamine / chloroform / 0 - 20 °C
2: ethanol / 2 h / 85 °C
3: potassium hydroxide / ethanol / 12 h / 80 °C
4: palladium 10 on activated carbon; hydrogen / methanol; dichloromethane / 3 h / 20 °C
View Scheme
参考文献
Stephenson, Karin A.; Wilson, Alan A.; Houle, Sylvain; Vasdev, Neil
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5506 - 5509
反应条件
1: pyridine / 2 h / 120 °C
2: KOH, pyridine / 4 h / 60 °C
3: 98 percent / sodium acetate / acetic acid / 4 h / 140 °C
4: 97 percent / H2 / 10percent Pd/C / ethyl acetate; methanol
View Scheme
参考文献
Horie, Tokunaru; Kourai, Hiroki; Fujita, Nobuhisa
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 12 p. 3773 - 3780
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in toluene
参考文献
Gasowska; Dabrowski; Drzewinski; Kenig; Tykarska; Przedmojski
Molecular Crystals and Liquid Crystals, 2004 , vol. 411, p. 231/[1273]-241/[1283]
反应条件
1: 95 percent / NEt3, 4-pyrrolidinopyridine / CH2Cl2 / 3 h / Heating
2: 64 percent / H2 / 10percent Pd-C / CH2Cl2; tetrahydrofuran / 3375.3 Torr
View Scheme
参考文献
Deschenaux, Robert; Marendaz, Jean-Luc; Santiago, Julio
Helvetica Chimica Acta, 1993 , vol. 76, # 2 p. 865 - 876
反应条件
1: pyridine / 2 h / 120 °C
2: KOH, pyridine / 4 h / 60 °C
3: 98 percent / sodium acetate / acetic acid / 4 h / 140 °C
4: 97 percent / H2 / 10percent Pd/C / ethyl acetate; methanol
5: 98 percent / AlCl3 / acetonitrile / 10 h / 70 °C
View Scheme
参考文献
Horie, Tokunaru; Kourai, Hiroki; Fujita, Nobuhisa
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 12 p. 3773 - 3780
反应条件
potassium carbonate in dichloromethane
T=20°C; 8 h;
参考文献
Batra, Sanjay; Sabnis, Yogesh A.; Rosenthal, Philip J.; Avery, Mitchell A.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 10 p. 2293 - 2299
