2-氯-1,3-噻唑-5-羰酰氯合成路线 （共 5 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C;
参考文献
HANGZHOU BENSHENG PHARACEUTICALS CO., LTD.; Xu, Rongzhen; Xie, Fuwen; Lai, Hongxi; Rong, Frank
Patent: US2013/178470 A1, 2013 ;
Location in patent: Paragraph 0108 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide in ethyl acetate T=65°C; 2 h;
参考文献
Sakai, Yasuhiro; Matsumoto, Toyomi; Tanaka, Akie; Shibuya, Masayuki
Heterocycles, 1993 , vol. 36, # 3 p. 565 - 573
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
HANGZHOU BENSHENG PHARACEUTICALS CO., LTD.; Xu, Rongzhen; Xie, Fuwen; Lai, Hongxi; Rong, Frank
Patent: US2013/178470 A1, 2013 ;
Location in patent: Paragraph 0109 ;
反应条件
pyridine in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
Sakai, Yasuhiro; Matsumoto, Toyomi; Tanaka, Akie; Shibuya, Masayuki
Heterocycles, 1993 , vol. 36, # 3 p. 565 - 573
反应条件
triethylamine in dichloromethane
T=20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/7041 A1, 2007 ;
Location in patent: Page/Page column 95-96 ;
WO 2007/007041 A1
