2-氯-3-氟-4-碘吡啶合成路线 （共 3 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-70°C; 4.66667 h; 2: With iodine in tetrahydrofuran; n-heptane; ethylbenzene T=-70 - 20°C; 2 h; 3: With Na2S2O5 in tetrahydrofuran; n-heptane; ethylbenzene; water Product distribution / selectivity;
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/35039 A1, 2012 ;
Location in patent: Page/Page column 107-108 ;
WO 2012/035039 A1
反应条件
1: 48 percent / EtNO2, 34percent HBF4 2: 1) (i-Pr)2NLi, 2) I2 / 1) THF, hexane, -75 deg C, 4 h, 2) THF, -75 deg C, 1 h View Scheme
参考文献
Tetrahedron, , vol. 49, # 16 p. 3325 - 3342
反应条件
1: 1) K2CO3 / 2) Pd(PPh3)4 / 1) EtOH, toluene, 0.5 h, 2) reflux, 48 h
2: 78 percent / Pd(PPh3)4 / toluene / 60 h / Heating
3: 83 percent / pyridinium chloride / 0.25 h / 210 °C
View Scheme
参考文献
Rocca; Marsais; Godard; Queguiner
Tetrahedron, 1993 , vol. 49, # 16 p. 3325 - 3342
