[(8R,9S,13S,14S)-13-甲基-17-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊二烯并[a]菲-3-基]氨基磺酸合成路线 （共 4 条）
→
148672-09-7[(8R,9S,13S,14S)-13-甲基-17-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊二烯并[a]菲-3-基]氨基磺酸
反应条件
amidosulfonyl chloride in 1-methyl-pyrrolidin-2-one T=0 - 20°C; sulfamoylation; 3 h;
参考文献
Okada; Iwashita; Koizumi
Tetrahedron Letters, 2000 , vol. 41, # 36 p. 7047 - 7051
→
148672-09-7[(8R,9S,13S,14S)-13-甲基-17-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊二烯并[a]菲-3-基]氨基磺酸
反应条件
formic acid in dichloromethane; N,N-dimethyl acetamide
反应条件
amidosulfonyl chloride in N,N-dimethyl-formamide 12 h; Ambient temperature;
参考文献
Schwarz, Sigfrid; Thieme, Ina; Richter, Margit; Undeutsch, Bernd; Henkel, Harry; Elger, Walter
Steroids, 1996 , vol. 61, # 12 p. 710 - 717
148672-09-7[(8R,9S,13S,14S)-13-甲基-17-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊二烯并[a]菲-3-基]氨基磺酸
→
反应条件
potassium hydroxide in water T=50°C; pH=1.74 - 13.69; Thermodynamic dataKinetics; pH-valueSolvent;
参考文献
Spillane, William J.; Malaubier, Jean-Baptiste
Tetrahedron Letters, 2010 , vol. 51, # 15 p. 2059 - 2062
