hydrogenchloride in methanol 2 h;

1: HCl / methanol / 2 h 2: N-methylmorpholine, 2,6-lutidine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h 3: 86 percent / HCl / methanol / 0.5 h / 35 °C 4: N-methylmorpholine, 2,6-lutidine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h 5: HCl / methanol / 0.5 h / 35 °C 6: N-methylmorpholine, 2,6-luditine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h 7: 91 percent / aq. NaOH / dimethylformamide / 6 h 8: 40 percent / aq. HCl / dioxane / 6 h View Scheme