[1,6-二氢-6-氧代-1-(2-氧代乙基)-2-苯基-5-嘧啶]氨基甲酸苯甲酯合成路线 （共 11 条）
反应条件
hydrogenchloride in tetrahydrofuran
8 h; Heating;
参考文献
Veale; Bernstein; Bryant; Ceccarelli; Damewood Jr.; Earley; Feeney; Gomes; Kosmider; Steelman; Thomas; Vacek; Williams; Wolanin; Woolson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 98 - 108
反应条件
hydrogenchloride; sodium periodate; osmium(VIII) oxide in tetrahydrofuran; ethanol; water; ethyl acetate
参考文献
Imperial Chemical Industries PLC
Patent: US5254558 A1, 1993 ;
反应条件
hydrogenchloride; sodium periodate; osmium(VIII) oxide in tetrahydrofuran; ethanol; water; ethyl acetate
参考文献
Zeneca Limited
Patent: US5736535 A1, 1998 ;
反应条件
1: methanol / 72 h / 5 °C
2: methanol / 1.5 h / 100 °C
3: pyridine, lithium iodide / 2 h / Heating
4: 1.) Et3N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h
5: 1N aq. HCl / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Veale; Bernstein; Bryant; Ceccarelli; Damewood Jr.; Earley; Feeney; Gomes; Kosmider; Steelman; Thomas; Vacek; Williams; Wolanin; Woolson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 98 - 108
反应条件
1: HCl / ethanol / 16 h / Ambient temperature
2: methanol / 72 h / 5 °C
3: methanol / 1.5 h / 100 °C
4: pyridine, lithium iodide / 2 h / Heating
5: 1.) Et3N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h
6: 1N aq. HCl / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Veale; Bernstein; Bryant; Ceccarelli; Damewood Jr.; Earley; Feeney; Gomes; Kosmider; Steelman; Thomas; Vacek; Williams; Wolanin; Woolson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 98 - 108
反应条件
1: NaHCO3 / tetrahydrofuran; H2O / 0 °C
2: aq. HCl / acetic acid / 2 h / 70 °C
View Scheme
参考文献
Ohmoto; Yamamoto; Horiuchi; Kojima; Hachiya; Hashimoto; Kawamura; Nakai; Toda
Synlett, 2001 , # 2 p. 299 - 301
反应条件
1: NaHCO3 / tetrahydrofuran; H2O / 0 °C
2: aq. HCl / acetic acid / 2 h / 70 °C
View Scheme
参考文献
Ohmoto; Yamamoto; Horiuchi; Kojima; Hachiya; Hashimoto; Kawamura; Nakai; Toda
Synlett, 2001 , # 2 p. 299 - 301
反应条件
1: pyridine / tetrahydrofuran / 0.33 h / 20 °C
2: 1,8-diazabicyclo[5.4.0]-7-undecene / tetrahydrofuran; H2O / 1 h / Heating
3: NaHCO3 / tetrahydrofuran; H2O / 0 °C
4: aq. HCl / acetic acid / 2 h / 70 °C
View Scheme
参考文献
Ohmoto; Yamamoto; Horiuchi; Kojima; Hachiya; Hashimoto; Kawamura; Nakai; Toda
Synlett, 2001 , # 2 p. 299 - 301
反应条件
1: 1,8-diazabicyclo[5.4.0]-7-undecene / tetrahydrofuran; H2O / 1 h / Heating
2: NaHCO3 / tetrahydrofuran; H2O / 0 °C
3: aq. HCl / acetic acid / 2 h / 70 °C
View Scheme
参考文献
Ohmoto; Yamamoto; Horiuchi; Kojima; Hachiya; Hashimoto; Kawamura; Nakai; Toda
Synlett, 2001 , # 2 p. 299 - 301
反应条件
1: With sodium chlorite; sodium dihydrogenphosphate in tetrahydrofuran; 2-methyl-but-2-ene; water; tert-butyl alcohol
T=0 - 20°C; 1.16667 h;
2: With hydrogenchloride; sodium hydrogencarbonate in tetrahydrofuran; 2-methyl-but-2-ene; water; tert-butyl alcohol
pH=3;
参考文献
Pharmacia Corporation
Patent: US6653316 B1, 2003 ;
Location in patent: Page/Page column 109-110 ;
US 6653316 B1
