6-氧代-2-苯基-5-[[(苯基甲氧基)羰基]氨基]-1(6h)-嘧啶乙酸合成路线 （共 13 条）
反应条件
1: pyridine / tetrahydrofuran / 0.33 h / 20 °C
2: 1,8-diazabicyclo[5.4.0]-7-undecene / tetrahydrofuran; H2O / 1 h / Heating
3: NaHCO3 / tetrahydrofuran; H2O / 0 °C
4: aq. HCl / acetic acid / 2 h / 70 °C
5: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 3 h / 0 - 20 °C
View Scheme
参考文献
Ohmoto; Yamamoto; Horiuchi; Kojima; Hachiya; Hashimoto; Kawamura; Nakai; Toda
Synlett, 2001 , # 2 p. 299 - 301
反应条件
1: 1,8-diazabicyclo[5.4.0]-7-undecene / tetrahydrofuran; H2O / 1 h / Heating
2: NaHCO3 / tetrahydrofuran; H2O / 0 °C
3: aq. HCl / acetic acid / 2 h / 70 °C
4: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 3 h / 0 - 20 °C
View Scheme
参考文献
Ohmoto; Yamamoto; Horiuchi; Kojima; Hachiya; Hashimoto; Kawamura; Nakai; Toda
Synlett, 2001 , # 2 p. 299 - 301
反应条件
1: 1.83 g / diethyl ether; methanol / 0 °C
2: 95 percent / hydrogen; HCl / Pd-C / ethyl acetate; methanol / 2 h / 20 °C
View Scheme
参考文献
Ohmoto, Kazuyuki; Okuma, Motohiro; Yamamoto, Tetsuya; Kijima, Hideomi; Sekioka, Tomohiko; Kitagawa, Kanji; Yamamoto, Shigeki; Tanaka, Kenji; Kawabata, Kazuhito; Sakata, Atsushi; Imawaka, Haruo; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1307 - 1323
