1-氟-4-(异氰基甲基)苯合成路线 （共 5 条）
反应条件
sodium carbonate; triethylamine; trichlorophosphate 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, 1 h; Yield given. Multistep reaction;
参考文献
Yu, Shu-Jing; Zhu, Cong; Bian, Qiang; Cui, Can; Du, Xiu-Jiang; Li, Zheng-Ming; Zhao, Wei-Guang
ACS Combinatorial Science, 2014 , vol. 16, # 1 p. 17 - 23
反应条件
tetra-(n-butyl)ammonium iodide in water; acetonitrile Ambient temperatureelectrolysis;
参考文献
Hess, Ulrich; Brosig; Komenda; Schaefer
Pharmazie, 1999 , vol. 54, # 6 p. 412 - 417
反应条件
1: 88 percent / 4 h / 0 - 20 °C 2: 1.) POCl3, Et3N, 2.) aq. Na2CO3 / 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, 1 h View Scheme
参考文献
Buyck, Thomas; Wang, Qian; Zhu, Jieping
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12714 - 12718
Angew. Chem., 2013 , vol. 125, # 48 p. 12946 - 12950,5
反应条件
2,6-dimethylpyridine in toluene T=80°C; Inert atmosphere;
参考文献
Dos Santos, Aurelie; El Kaim, Laurent; Grimaud, Laurence; Ronsseray, Caroline
Chemical Communications, 2009 , # 26 p. 3907 - 3909
反应条件
sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; 2 h; Inert atmosphere;
参考文献
Buyck, Thomas; Wang, Qian; Zhu, Jieping
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12714 - 12718
Angew. Chem., 2013 , vol. 125, # 48 p. 12946 - 12950,5
