(E)-3-[2-环丙基-4-(4-氟苯基)-3-喹啉-2-丙烯醛合成路线 （共 17 条）
反应条件
diisobutylaluminium hydride in toluene T=-15°C; 1 h;
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
sodium hydride in tetrahydrofuran T=63°C; 11 h; Product distribution / selectivity;
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP1614682 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium hydride in tetrahydrofuran T=63°C; 11 h; Product distribution / selectivity;
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP1614682 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium hydride in tetrahydrofuran T=63°C; 11 h; Product distribution / selectivity;
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP1614682 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; water T=20°C; 24 h;
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: tetrahydrofuran; hexane / -78 °C 2.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / -78 °C 3.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2.1: DIBAL-H / toluene / 2 h / 0 °C 3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 4.2: tetrahydrofuran; hexane / -78 °C 5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2.1: DIBAL-H / toluene / 2 h / 0 °C 3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 4.2: tetrahydrofuran; hexane / -78 °C 5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: DIBAL-H / toluene / 2 h / 0 °C 2.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 3.2: tetrahydrofuran; hexane / -78 °C 4.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
