(E)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-5-羟基-3-氧代-6-庚烯酸乙酯合成路线 （共 13 条）
反应条件
n-butyllithium; sodium hydride in tetrahydrofuran; hexane T=-10°C; 3 h;
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
Rhodotorula glutinis var dairenensis IFO0415 in dimethyl sulfoxide T=27°C; pH=7; 12 h; aerobic conditionspotassium phosphate buffer (pH 7.0); Product distribution / selectivity;
参考文献
US2004/30139 A1, ;
Page 13-14 ;
反应条件
1.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / -78 °C 3.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 4.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: tetrahydrofuran; hexane / -78 °C 2.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 3.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: 86.5 percent / diisobutylaluminum hydride / toluene / 1 h / -15 °C 2: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2.1: DIBAL-H / toluene / 2 h / 0 °C 3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 4.2: tetrahydrofuran; hexane / -78 °C 5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 6.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2.1: DIBAL-H / toluene / 2 h / 0 °C 3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 4.2: tetrahydrofuran; hexane / -78 °C 5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 6.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: DIBAL-H / toluene / 2 h / 0 °C 2.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 3.2: tetrahydrofuran; hexane / -78 °C 4.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 5.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: tetrahydrofuran; hexane / -78 °C 2.1: 85.1 percent / aq. NaOH; trioctylmethylammonium chloride / toluene / 2 h / 20 °C 3.1: 86.5 percent / diisobutylaluminum hydride / toluene / 1 h / -15 °C 4.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: pyridinium chlorochromate; sodium acetate / CH2Cl2 / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / -78 °C 3.1: 85.1 percent / aq. NaOH; trioctylmethylammonium chloride / toluene / 2 h / 20 °C 4.1: 86.5 percent / diisobutylaluminum hydride / toluene / 1 h / -15 °C 5.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
