(E)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-5-羟基-3-氧代-6-庚烯酸乙酯合成路线 （共 13 条）
反应条件
1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 2: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: NaBH4; Et2BOMe / -78 °C 2.1: aq. NaOH 2.2: (+)-α-methylbenzylamine View Scheme
参考文献
Hara, Mari; Takuma, Yuki; Katsurada, Manabu; Hosokawa, Akemi; Matsumoto, Youichi; Kasuga, Yuzo; Watanabe, Naoyuki
Patent: US2004/30139 A1, 2004 ;
Location in patent: Page 25-26 ;
反应条件
1.1: NaBH4; Et2BOMe / -78 °C
2.1: aq. NaOH
2.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
