(2S)-2-氨基-N-[(1S,4R)-7,7-二甲基-1-[[4-(2-甲基苯基)哌嗪-1-基]磺酰基甲基]-6-双环[2.2.1]庚烷基]-4-甲基磺酰基丁酰胺合成路线 (共 2 条)
反应条件
trifluoroacetic acid in dichloromethane 1 h;
参考文献
Williams; Anderson; Ball; Bock; Carroll; Chiu -; Clineschmidt; Culberson; Erb; Evans; Fitzpatrick; Freidinger; Kaufman; Lundell; Murphy; Pawluczyk; Perlow; Pettibone; Pitzenberger; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 565 - 571
反应条件
1: 98 percent / HOBT, EDC, diisopropylethylamine / dimethylformamide / 18 h 2: 98 percent / TFA / CH2Cl2 / 1 h View Scheme
参考文献
Williams; Anderson; Ball; Bock; Carroll; Chiu -; Clineschmidt; Culberson; Erb; Evans; Fitzpatrick; Freidinger; Kaufman; Lundell; Murphy; Pawluczyk; Perlow; Pettibone; Pitzenberger; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 565 - 571