R-(+)-2-甲基-1-苯基-1-丙醇合成路线 （共 41 条）
反应条件
potassium tert-butylate; hydrogen; [Ru(η4-COD)(η3-methylallyl)2]; (R)-Ph-BINAN-H-Py in isopropyl alcohol
T=25°C; P=38000 Torr; 18 h;
参考文献
Huang, Hanmin; Okuno, Tomoko; Tsuda, Kazuomi; Yoshimura, Masahiro; Kitamura, Masato
Journal of the American Chemical Society, 2006 , vol. 128, # 27 p. 8716 - 8717
反应条件
lt;lt;(1S,2R)-6,6-dimethylbicyclolt;3.1.1gt;heptan-2-ylgt;methylgt;aluminum dichloride in diethyl ether
4 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Giacomelli, Giampaolo; Lardicci, Luciano; Palla, Fabio
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 310 - 313
反应条件
1: (1S,3S,4R)-2-benzyl-3-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane tetrafluoroborate With lithium hexamethyldisilazane in tetrahydrofuran; dichloromethane
T=-78°C; 1 h;
2: B-iPr-9-BBN in tetrahydrofuran; dichloromethane
T=-100 - 0°C;
3: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; dichloromethane
T=0 - 20°C; Further stages.;
参考文献
Fang, Guang Y.; Wallner, Olov A.; Di Blasio, Nadia; Ginesta, Xavier; Harvey, Jeremy N.; Aggarwal, Varinder K.
Journal of the American Chemical Society, 2007 , vol. 129, # 47 p. 14632 - 14639
反应条件
CH2CH2O(C10H5O)4H2P2N2(CH3)4; [{RuCl2(cymene)}2]; potassium carbonate in water; toluene
T=60°C; 16 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Yamamoto, Yasunori; Shirai, Tomohiko; Watanabe, Momoko; Kurihara, Kazunori; Miyaura, Norio
Molecules, 2011 , vol. 16, # 6 p. 5020 - 5034
反应条件
(1S,2R)-(+)-erythro-2-amino-1,2-diphenylethanol; benzoic acid in hexane
T=20°C; 12 h;
参考文献
Kodama, Koichi; Kobayashi, Yuka; Saigo, Kazuhiko
Chemistry - A European Journal, 2007 , vol. 13, # 7 p. 2144 - 2152
反应条件
chiral 2-(3',5'-di-tert-butylphenyl)-4,4,8-trimethyl-2-phosphabicyclolt;3.3.0gt;octane in n-heptane
T=-40°C; 42 h; Title compound not separated from byproducts;
参考文献
Vedejs, Edwin; Daugulis, Olafs
Journal of the American Chemical Society, 1999 , vol. 121, # 24 p. 5813 - 5814
反应条件
5-Deoxy-1,2-O-isopropylidene-5-morpholino-α-D-xylofuranose in toluene
T=0°C; Addition; 4 h;
参考文献
Yang, Weon Ki; Cho, Byung Tae
Tetrahedron Asymmetry, 2000 , vol. 11, # 14 p. 2947 - 2953
反应条件
1: With MnIII(L-5-t-Bu)(Cl); 1-butyl-2,6-dimethyl-pyridinium; bromide in dichloromethane; water
T=20°C;
2: With [bis(acetoxy)iodo]benzene in dichloromethane; water
T=20°C; 0.1 h;
参考文献
Cheng, Qigan; Deng, Fanguo; Xia, Chungu; Sun, Wei
Tetrahedron Asymmetry, 2008 , vol. 19, # 20 p. 2359 - 2362
反应条件
(1R,2R,4S,5S)-4,8,8-triMe-2-Ph-2-phosphabicyclo[3.3.0]octane in toluene
T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Vedejs, Edwin; Daugulis, Olafs
Journal of the American Chemical Society, 2003 , vol. 125, # 14 p. 4166 - 4173
反应条件
Birman's catalyst; nicotinic anhydride in dichloromethane
T=0°C; 12 h; Resolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Mukaiyama, Teruaki
Helvetica Chimica Acta, 2012 , vol. 95, # 10 p. 1891 - 1911,21
Title/Abstract Full Text Show Details
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Mukaiyama, Teruaki
Helvetica Chimica Acta, 2012 , vol. 95, # 10 p. 1891 - 1911
