R-(+)-2-甲基-1-苯基-1-丙醇合成路线 （共 41 条）
反应条件
1: 1-hydroxy-2-(1-methyl)-propylbenzene With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran
T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate;
2: triphenyl-silyl chloride in tetrahydrofuran
T=-78°C; 48 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Sheppard, Cody I.; Taylor, Jessica L.; Wiskur, Sheryl L.
Organic Letters, 2011 , vol. 13, # 15 p. 3794 - 3797
反应条件
toluene-4-sulfonic acid in methanol
3 h;
参考文献
Noe, Christian R.
Chemische Berichte, 1982 , vol. 115, # 4 p. 1591 - 1606
反应条件
1: triphenyl boroxine With diethylzinc in toluene
T=60°C; 4 h;
2: isobutyraldehyde With (S)-dendritic pyrrolidinylmethanol C116H105NO15 in toluene
T=-15°C; 6 h; Title compound not separated from byproducts;
参考文献
Liu, Xin Yuan; Wu, Xiao Yu; Chai, Zhuo; Wu, Yong Yong; Zhao, Gang; Zhu, Shi Zheng
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7432 - 7435
反应条件
dilithium salt of (2S,5S)-2, 5-diisopropylpiperazine
1) toluene, hexane, RT, 30 min, 2) RT, 20h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Niwa, Seiji; Soai, Kenso
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , p. 2717 - 2720
反应条件
1: 1-hydroxy-2-(1-methyl)-propylbenzene With (S,R(P))-2-phenyl-2,3-dihydroimidazo[1,2-a]pyrindinyl-pentaphenylcyclopentadienyliron; N-ethyl-N,N-diisopropylamine in toluene
T=0°C; 0.0833333 h;
2: propionic acid anhydride in toluene
T=0°C; 8 h; optical yield given as percent eeenantioselective reaction;
参考文献
Hu, Bin; Meng, Meng; Wang, Zheng; Du, Wenting; Fossey, John S.; Hu, Xinquan; Deng, Wei-Ping
Journal of the American Chemical Society, 2010 , vol. 132, # 47 p. 17041 - 17044
反应条件
(R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in chloroform
T=0°C; 8 h; Product distribution; Further Variations:Reagents;
参考文献
Birman, Vladimir B.; Jiang, Hui
Organic Letters, 2005 , vol. 7, # 16 p. 3445 - 3447
反应条件
(5aS,10aS)-(-)-Octahydro-5H,10H-dipyrrololt;1,2-a:1',2'-dgt;pyrazin in tetrahydrofuran; toluene
T=-100°C; 5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Zadel, Guido; Breitmaier, Eberhard
Chemische Berichte, 1994 , vol. 127, # 7 p. 1323 - 1326
反应条件
tetra-n-butylammonium tetrafluoroborate; (1R,2S)-(-)-N,N-dimethylephedrinium tetrafluoroborate in water; N,N-dimethyl-formamide
Electrolysis;
参考文献
Yadav, Ashok K.; Singh, Arpita
Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 3 p. 587 - 588
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 12 h; Title compound not separated from byproducts.;
参考文献
Shiina, Isamu; Nakata, Kenya
Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8314 - 8317
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 12 h; Title compound not separated from byproducts.;
参考文献
Shiina, Isamu; Nakata, Kenya
Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8314 - 8317
