tetrabutyl ammonium fluoride in tetrahydrofuran T=45°C; 72 h;

<b>Multi-step reaction with 5 steps<br /> </b>1: 91 percent / Ph₃P, H₂O, pyridine<br />2: 92 percent / NaHCO₃ / dioxane; H₂O<br />3: tetrazole / CH₂Cl₂; acetonitrile / 0.5 h<br />4: iodine, pyridine, water / CH₂Cl₂ <br />5: 95 percent / 33percent HNMe₂ / ethanol / 72 h / 45 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 92 percent / NaHCO₃ / dioxane; H₂O<br />2: tetrazole / CH₂Cl₂; acetonitrile / 0.5 h<br />3: iodine, pyridine, water / CH₂Cl₂ <br />4: 95 percent / 33percent HNMe₂ / ethanol / 72 h / 45 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: tetrazole / CH₂Cl₂; acetonitrile / 0.5 h<br />2: iodine, pyridine, water / CH₂Cl₂ <br />3: 95 percent / 33percent HNMe₂ / ethanol / 72 h / 45 &deg;C<br /> <br /> &nbsp;