7,10-二[O-(三乙基硅烷基)]-10-去乙酰基浆果赤霉素III合成路线 （共 5 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=25°C; Inert atmosphere; 2: With lithium bromide in tetrahydrofuran T=20 - 70°C; Inert atmosphere;
参考文献
Kung, Liang-Rern; Chang, Shih-Sheng; Fang, Tung-Shen; Lin, Shu-Fen; Chang, Cheng-Chang; Chen, Chia-Hui; Hung, Yi-Ting; Cheng, Ming-Ching
Patent: US2012/149925 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 7-O-triethylsilyl-10-deacetyl baccatin III With n-butyllithium in tetrahydrofuran 2: triethylsilyl chloride in tetrahydrofuran T=0°C;
参考文献
Florida State University
Patent: EP1193252 A2, 2002 ;
Location in patent: Page 11 ;
反应条件
1H-imidazole in N,N-dimethyl-formamide 96 h; Ambient temperature; Further byproducts given;
参考文献
Tetrahedron, , vol. 55, # 21 p. 6567 - 6576
反应条件
1H-imidazole; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=0°C; 0.5 h;
参考文献
Florida State University
Patent: US6727369 B1, 2004 ;
Location in patent: Page column 39 - 40 ;
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / -15 - 5 °C / Inert atmosphere 1.2: 1 h / -5 - 5 °C / Inert atmosphere 1.3: 3 h / Inert atmosphere 2.1: hydrogenchloride / water; methanol / 27 h / -5 - 30 °C View Scheme
参考文献
Kung, Liang-Rern; Chang, Shih-Sheng; Fang, Tung-Shen; Lin, Shu-Fen; Chang, Cheng-Chang; Chen, Chia-Hui; Hung, Yi-Ting; Cheng, Ming-Ching
Patent: US2012/149925 A1, 2012 ;
