(3R,4S)-4-苯基-3-[(三乙基硅烷基)氧基]-2-氮杂环丁酮合成路线 （共 12 条）
反应条件
1H-imidazole in tetrahydrofuran T=0 - 20°C; 2.3 h;
参考文献
Walker; Swigor; Kant; Schroeder
Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 10 p. 973 - 980
反应条件
1: With chloro-trimethyl-silane in diethyl ether T=20°C; 1 h; 2: With 1,1-dimethylethylmagnesium chloride in diethyl ether T=20°C; 3 h; Further stages.;
参考文献
Beusker, Patrick H.; Veldhuis, Harald; Van Den Bossche, Bianca A. C.; Scheeren, Hans W.
European Journal of Organic Chemistry, 2001 , # 9 p. 1761 - 1768
反应条件
aqueous KOH in tetrahydrofuran; hexane; ethyl acetate; acetonitrile
反应条件
1.1: 96 percent / triethylamine / tetrahydrofuran 2.1: 2.58 g / H2 / Pd/C / ethyl acetate / 20 h 3.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 3.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1761 - 1768
反应条件
1.1: 96 percent / triethylamine / tetrahydrofuran 2.1: 2.58 g / H2 / Pd/C / ethyl acetate / 20 h 3.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 3.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1761 - 1768
反应条件
1.1: 2.58 g / H2 / Pd/C / ethyl acetate / 20 h 2.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 2.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1761 - 1768
反应条件
1: 65 percent / KOH / H2O 2: 94 percent / pyridine View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 21 p. 3559 - 3562
反应条件
1: 87 percent / Ce(NH4)2(NO3)4 / acetonitrile; H2O 2: 65 percent / KOH / H2O 3: 94 percent / pyridine View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 21 p. 3559 - 3562
反应条件
1: 100 percent / NBu4F / tetrahydrofuran 2: pyridine View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C;
参考文献
Paterson, Ian; Naylor, Guy J.; Fujita, Takeshi; Guzman, Esther; Wright, Amy E.
Chemical Communications, 2010 , vol. 46, # 2 p. 261 - 263
