(3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-1-甲酸叔丁酯合成路线 (共 6 条)
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C;
参考文献
Paterson, Ian; Naylor, Guy J.; Fujita, Takeshi; Guzman, Esther; Wright, Amy E.
Chemical Communications, 2010 , vol. 46, # 2 p. 261 - 263
反应条件
1: pyridine 2: Et3N, DMAP / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152
反应条件
1: pyridine 2: Et3N, DMAP / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152
反应条件
1: 100 percent / NBu4F / tetrahydrofuran 2: pyridine 3: Et3N, DMAP / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152
反应条件
1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme
参考文献
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman
Patent: WO2012/142117 A1, 2012 ;