2,6-二甲基苯甲酸甲酯合成路线 （共 33 条）
反应条件
1: LiAlH4 2: SOCl2 3: aq. ethanol View Scheme
参考文献
van Zanten,B.; Nauta,W.
Recueil des Travaux Chimiques des Pays-Bas, 1960 , vol. 79, p. 1211 - 1222
反应条件
sodium hydroxide; N-bromosuccinmide 1.) CCl4, reflux, 3 h, irradiation, 2.) reflux, 35 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
反应条件
1: LiAlH4 / tetrahydrofuran / 4 h 2: Me3SiCl / dimethylsulfoxide / 0.5 h 3: dimethylformamide 4: hydrazine hydrate / ethanol / 3 h / Heating View Scheme
参考文献
Mimoto, Tsutomu; Kato, Ryohei; Takaku, Haruo; Nojima, Satoshi; Terashima, Keisuke; Misawa, Satoru; Fukazawa, Tominaga; Ueno, Takamasa; Sato, Hideharu; Shintani, Makoto; Kiso, Yoshiaki; Hayashi, Hideya
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1789 - 1802
反应条件
in water; N,N-dimethyl-formamide T=35°C; benzenemethanethiolates of other alkali metals; Rate constant;
参考文献
Cacciapaglia, R.; Mandolini, L.; Castelli, V. Van Axel
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, p. 347 - 350
反应条件
lithium aluminium tetrahydride
参考文献
Mimoto, Tsutomu; Kato, Ryohei; Takaku, Haruo; Nojima, Satoshi; Terashima, Keisuke; Misawa, Satoru; Fukazawa, Tominaga; Ueno, Takamasa; Sato, Hideharu; Shintani, Makoto; Kiso, Yoshiaki; Hayashi, Hideya
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1789 - 1802
反应条件
1: LiAlH4 / tetrahydrofuran / 4 h 2: Me3SiCl / dimethylsulfoxide / 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 10 p. 1789 - 1802
参考文献
Brown; Grayson
Journal of the American Chemical Society, 1953 , vol. 75, p. 20,23
反应条件
1: NBS / CCl4 / 6 h / Heating; Irradiation 2: 1 h / 180 °C / 10 Torr 3: 68.6 percent / H2, Ca(OH)2 / 10percent Pd/C / dioxane / 48 h / 2068.6 Torr View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
反应条件
sodium hydroxide; N-bromosuccinmide 1.) CCl4, reflux, 3 h, irradiation, 2.) reflux, 35 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
反应条件
1: NBS, benzoyl peroxide / CCl4 / 0.5 h / Irradiation
2: CCl4; dimethylformamide / 1 h / Ambient temperature
3: LiAlH4 / tetrahydrofuran / 1 h / 0 °C
4: 86 percent / Me2S, NBS / CH2Cl2 / 3 h / 0 °C
View Scheme
参考文献
Ghera, E.; Maurya, R.; Ben-David, Y.
Tetrahedron Letters, 1986 , vol. 27, # 33 p. 3935 - 3938
