1: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 2: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 3: 4-(aminomethyl)piperidine / CHCl3 4: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.5 h 5: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 6: 1.) 95 percent TFA / 1.) 2 h, 2.) water, G-15 Sephadex View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.5 h<br />2: 4-(aminomethyl)piperidine / CHCl₃ / 0.5 h<br />3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 4-(aminomethyl)piperidine / CHCl₃ / 0.5 h<br />2: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3584612', constants.ctx, '0')">benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605301', constants.ctx, '0')">N-ethyl-N,N-diisopropylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1731042', constants.ctx, '0')">chloroform</a> <br />0.166667&nbsp;h;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1733101', constants.ctx, '0')">n-octanethiol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '263610', constants.ctx, '0')">bis (1-methyl-(1H)-tetrazol-5-yl)-disulfide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3570522', constants.ctx, '0')">tetrabutyl ammonium fluoride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '4635293', constants.ctx, '0')">O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605301', constants.ctx, '0')">N-ethyl-N,N-diisopropylamine</a> <br />&nbsp;1.) DMF, a) ultrasound, 1 min, b) 3 min, 2.) DMF, 10 min;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;