1: 2-[2-(trifluoromethyl)phenoxy]tetrahydro-2H-pyrane With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; diethyl ether T=-20 - 20°C; 1.33333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; diethyl ether T=-30 - -20°C; 1 h;

n-butyllithium; iodine 1) THF, -78 deg C, 30 min, 2) a) THF, -78 deg C, 10 min, b) to room temperature; Yield given. Multistep reaction;

1: 1) BuLi, 2) iodine / 1) THF, -78 deg C, 30 min, 2) a) THF, -78 deg C, 10 min, b) to room temperature 2: 47 percent / dimethylformamide; hexamethylphosphoric acid triamide / 1.5 h / 60 °C View Scheme