(3R,4S)-1-苯甲酰-3-[(三乙基硅)氧基]-4-苯基-2-氮杂环丁酮合成路线 （共 10 条）
参考文献
Brown, Stephen; Jordan, Allan M.; Lawrence, Nicholas J.; Pritchard, Robin G.; McGown, Alan T.
Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3559 - 3562
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Bristol-Myers Squibb Company
Patent: US5478854 A1, 1995 ;
反应条件
1.1: 96 percent / triethylamine / tetrahydrofuran 2.1: 2.58 g / H2 / Pd/C / ethyl acetate / 20 h 3.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 3.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C 4.1: 87 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1761 - 1768
反应条件
1.1: 96 percent / triethylamine / tetrahydrofuran 2.1: 2.58 g / H2 / Pd/C / ethyl acetate / 20 h 3.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 3.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C 4.1: 87 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1761 - 1768
反应条件
1.1: 2.58 g / H2 / Pd/C / ethyl acetate / 20 h 2.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 2.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C 3.1: 87 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1761 - 1768
反应条件
1.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 1.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C 2.1: 87 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1761 - 1768
反应条件
1: 94 percent / pyridine 2: 98 percent / NEt3 View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 21 p. 3559 - 3562
反应条件
1: 65 percent / KOH / H2O 2: 94 percent / pyridine 3: 98 percent / NEt3 View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 21 p. 3559 - 3562
反应条件
1: 87 percent / Ce(NH4)2(NO3)4 / acetonitrile; H2O 2: 65 percent / KOH / H2O 3: 94 percent / pyridine 4: 98 percent / NEt3 View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 21 p. 3559 - 3562
反应条件
1: 77 percent / LHMDS / tetrahydrofuran / -78 - 0 °C 2: 84 percent / Zn; aq. AcOH / 16 h / 20 °C View Scheme
参考文献
Nicolaou; Nantermet; Ueno; Guy
Journal of the Chemical Society - Series Chemical Communications, 1994 , # 3 p. 295 - 296
