6-氯-n-甲氧基-n-甲基烟酰胺合成路线 （共 13 条）
反应条件
pyridine in chloroform T=20°C; 1 h;
参考文献
Dehmlow, Henrietta; Aebi, Johannes D.; Jolidon, Synese; Ji, Yu-Hua; Von der Mark, Elisabeth M.; Himber, Jacques; Morand, Olivier H.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 15 p. 3354 - 3370
参考文献
PFIZER PRODUCTS INC.?
Patent: WO2005/60967 A1, 2005 ;
Location in patent: Page/Page column 21 ;
WO 2005/060967 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
ABBOTT GMBH and; CO. KG; TURNER, Sean Colm; BAKKER, Margaretha Henrica Maria; HORNBERGER, Wilfried; WOLTER, Falko Ernst
Patent: WO2010/109005 A1, 2010 ;
Location in patent: Page/Page column 54 ;
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran T=-30°C; 1 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
WO2005/118542 A1, ;
Page/Page column 85-86 ;
WO 2005/118542 A1
反应条件
1: SOCl2 / 3.5 h / Heating 2: 100 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 15 p. 3354 - 3370
反应条件
in tetrahydrofuran Substitution;
参考文献
Piotrowski, David W.
Synlett, 1999 , # 7 p. 1091 - 1093
反应条件
in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
SCHERING CORPORATION
Patent: EP1091956 B1, 2004 ;
Location in patent: Page 7; 24 ;
反应条件
in tetrahydrofuran Substitution;
参考文献
Piotrowski, David W.
Synlett, 1999 , # 7 p. 1091 - 1093
反应条件
diisobutylaluminium hydride
参考文献
PFIZER PRODUCTS INC.?
Patent: WO2005/60967 A1, 2005 ;
Location in patent: Page/Page column 21 ;
WO 2005/060967 A1
反应条件
1: in tetrahydrofuran; diethyl ether
T=25°C; 18 h; Heating / reflux;
2: With ammonium chloride in tetrahydrofuran; diethyl ether; water
参考文献
Brewster, William Kirkland; Klittich, Carla Jean Rasmussen; Balko, Terry William; Breaux, Nneka Tuere; Erickson, William Randal; Hunter, James Edward; Lowe, Christian Thomas; Ricks, Michael John; Siddall, Thomas Lyman; Yerkes, Carla Nanette; Zhu, Yuanming
Patent: US2006/89370 A1, 2006 ;
Location in patent: Page/Page column 35 ;
