1: With sodium sulfide hydrate in 1-methyl-pyrrolidin-2-one T=20 - 185°C; 2: With succinic acid in 1-methyl-pyrrolidin-2-one; water T=10 - 90°C; pH=10 - 11;

1: With Na-selectride in tetrahydrofuran; toluene T=20 - 115°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water; toluene T=10°C; pH=1.0; Reflux; 3: With sodium hydroxide in water T=20°C; pH=10.3 - 10.5; Product distribution / selectivity;

in 3,6,9,12,15,18,21,24,27-nonaoxanonacosane-1,29-diol T=190°C; 3 h; Product distribution / selectivity;

1: With sodium tris(acetoxy)borohydride in isopropanol acetate T=28°C; Industry scaleInert atmosphere; 2: With sodium hydroxide in isopropanol acetate; water; isopropyl alcohol T=20°C; pH=9.5 - 10; Reflux; 3: With hydrogenchloride in water; isopropyl alcohol T=20 - 25°C; Product distribution / selectivity;

1: With sodium tetrahydroborate; formaldehyd in methanol T=0°C; 0.25 h; 2: With water; citric acid in isopropyl alcohol T=20°C; pH=9 - 10; 0.0833333 h; Product distribution / selectivity;

1: N,N-Didesmethyldesvenlafaxine With n-butyllithium in hexane; dimethyl sulfoxide T=0 - 20°C; 2: methyl iodide in hexane; dimethyl sulfoxide 0.5 h; Product distribution / selectivity;