2-BOC-7-羧基-1,2,3,4-四氢异喹啉合成路线 （共 7 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=60°C; 3 h;
参考文献
ARENA PHARMACEUTICALS, INC.; TRAN, Thuy-Anh; BLACKBURN, Anthony C.; KRAMER, Bryan A.; NAGURA, Maiko; SAGE, Carleton R.; SHIN, Young-Jun; ZOU, Ning
Patent: WO2013/70657 A1, 2013 ;
Location in patent: Page/Page column 153; 175 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane
参考文献
Eli Lilly and Company
Patent: US5491166 A1, 1996 ;
反应条件
1: 2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid With sodium hydroxide in water 2: di-tert-butyl dicarbonate in water T=20°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C 2: lithium hydroxide hydrate; water / tetrahydrofuran; methanol / 3 h / 60 °C View Scheme
反应条件
1.1: AlCl3, aluminium chloride 2.1: sodium hydroxide / water 2.2: 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661
反应条件
4-(N,N-dimethlyamino)pyridine in methanol
T=50°C;
参考文献
4SC AG
Patent: EP2100879 A1, 2009 ;
Location in patent: Page/Page column 17 ;
EP 2100879 A1
反应条件
dimethylsulfide borane complex in tetrahydrofuran
T=20°C;
参考文献
ABBOTT GMBH and CO. KG; ABBOTT LABORATORIES; POHLKI, Frauke; AMBERG, Wilhelm; LANGE, Udo; OCHSE, Michael; BEHL, Berthold; HORNBERGER, Wilfried; MEZLER, Mario; HUTCHINS, Charles
Patent: WO2012/20134 A1, 2012 ;
Location in patent: Page/Page column 77-78 ;
WO 2012/020134 A1
