1: N-methylmorpholine 2: 71 percent / pyridine / CH2Cl2 / 0 °C 3: 86 percent / PPh3 / o-xylene / 24 h / Heating 4: 91 percent / H2 / Pd/C / methanol / 12 h / 20 °C / 4500.45 Torr View Scheme

1: 87 percent / Et3N / tetrahydrofuran / 20 °C 2: 86 percent / PPh3 / o-xylene / 24 h / Heating 3: 91 percent / H2 / Pd/C / methanol / 12 h / 20 °C / 4500.45 Torr View Scheme