4-(4-氟苯甲酰基)丁酸合成路线 （共 5 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=0°C; 0.5 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2004/99132 A2, 2004 ;
Location in patent: Page 7-8 ;
反应条件
hydrogenchloride; sodium hydrogencarbonate; AlCl3 in o-di-fluorobenzene; water
参考文献
Schering Corporation
Patent: US6207822 B1, 2001 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
参考文献
HANMI PHARM. CO., LTD.; KIM, Gi Jeong; KIM, Choong Hahn; CHANG, Ji Yeon; KIM, Nam Du; CHANG, Young Kil; LEE, Gwan Sun
Patent: WO2010/71358 A2, 2010 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: pivaloyl chloride; 5-(4-fluorophenyl)-5-oxopentanoic acid With 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide T=2 - 20°C; 1.5 h; 2: (S)-5-phenyl-1,3-oxazolidine-2-one With 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide T=30 - 35°C; 2 h;
参考文献
MICROBIA, INC.
Patent: US2008/287663 A1, 2008 ;
Location in patent: Page/Page column 23 ;
反应条件
1: 5-(4-fluorophenyl)-5-oxopentanoic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide
T=25 - 30°C; 3 h;
2: morpholine in N,N-dimethyl-formamide
T=40 - 45°C; 10 h;
参考文献
GLENMARK PHARMACEUTICALS LIMITED
Patent: WO2007/17705 A1, 2007 ;
Location in patent: Page/Page column 6; 8 ;
