2-甲基-2-丙基(3,4-二羟基-1-苯基-2-丁烷基)氨基甲酸酯合成路线 （共 33 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 16 h; 2: With water in tetrahydrofuran T=0 - 12°C; 0.333333 h;
参考文献
G. D. Searle and Co.
Patent: US6388132 B1, 2002 ;
Location in patent: Page column 43 ;
反应条件
sodium methylate in methanol T=20 - 30°C; 2 h; Inert atmosphere;
参考文献
ScinoPharm Singapore PTE, Ltd.
Patent: US2012/220784 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
hydrogen; 10 palladium on active carbon in ethyl acetate T=20°C; Hydrogenation; Acylation; P=760 Torr;
参考文献
Catasus, Monica; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9309 - 9312
反应条件
hydrogen; palladium dihydroxide in ethyl acetate 12 h;
参考文献
Ghosh, Arun K.; Hussain, Khaja Azhar; Fidanze, Steve
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6080 - 6082
反应条件
anhydrous sodium hydrogen carbonate in tetrahydrofuran; water
参考文献
Kaneka Corporation
Patent: US5744630 A1, 1998 ;
反应条件
water; triethylamine in 1,4-dioxane T=20°C; 3 h;
参考文献
Buesking, Andrew W.; Baguley, Tyler D.; Ellman, Jonathan A.
Organic Letters, 2011 , vol. 13, # 5 p. 964 - 967
反应条件
trifluoroacetic acid in methanol; water T=20°C; 48 h;
参考文献
Badorrey, Ramon; Diaz-de-Villegas, Maria D.; Galvez, Jose A.
Tetrahedron Asymmetry, 2009 , vol. 20, # 19 p. 2226 - 2229
反应条件
1: CH2Cl2 / 3 h / 23 °C 2: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h View Scheme
参考文献
Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J.; Jirgensons, Aigars
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 373 - 377
反应条件
1: Ti(O-i-Pr)2(N3)2 / benzene / Heating 2: H2 / Pd/C / ethyl acetate / 20 °C View Scheme
参考文献
Catasus, Monica; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9309 - 9312
反应条件
1: CH2Cl2 / 3 h / 23 °C 2: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h View Scheme
参考文献
Ghosh, Arun K.; Hussain, Khaja Azhar; Fidanze, Steve
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6080 - 6082
