2-甲基-2-丙基(3,4-二羟基-1-苯基-2-丁烷基)氨基甲酸酯合成路线 （共 33 条）
反应条件
1: KOH / ethanol; H2O / 17 h / Heating 2: CH2Cl2 / 3 h / 23 °C 3: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h View Scheme
参考文献
Ghosh, Arun K.; Hussain, Khaja Azhar; Fidanze, Steve
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6080 - 6082
反应条件
osmium(VIII) oxide; 4-methylmorpholine N-oxide Yield given;
参考文献
Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J.; Jirgensons, Aigars
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 373 - 377
反应条件
1: Ti(O-i-Pr)4; D(-)-DIPT; t-BuOOH / CH2Cl2 / -20 °C 2: Ti(O-i-Pr)2(N3)2 / benzene / Heating 3: H2 / Pd/C / ethyl acetate / 20 °C View Scheme
参考文献
Pico, Anna; Moyano, Albert; Pericas, Miquel A.
Journal of Organic Chemistry, 2003 , vol. 68, # 13 p. 5075 - 5083
反应条件
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h / Heating 1.2: tetrahydrofuran / 0.5 h / 0 °C 2.1: aq. H2O2; aq. NaHCO3 / methanol; tetrahydrofuran / 2.5 h / 70 °C 3.1: 1.14 g / H2 / 5 percent Pd/C / ethanol / 6.5 h / 50 °C 4.1: methanol / 2 h / 20 °C View Scheme
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
1: 1.14 g / H2 / 5 percent Pd/C / ethanol / 6.5 h / 50 °C 2: methanol / 2 h / 20 °C View Scheme
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
1: aq. H2O2; aq. NaHCO3 / methanol; tetrahydrofuran / 2.5 h / 70 °C 2: 1.14 g / H2 / 5 percent Pd/C / ethanol / 6.5 h / 50 °C 3: methanol / 2 h / 20 °C View Scheme
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Remuzon, Philippe; Dussy, Christian; Jacquet, Jean-Pierre; Roty, Pascale; Bouzard, Daniel
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1181 - 1188
反应条件
1: hydrogenchloride; water / 1,4-dioxane / 20 h / 20 °C / Water bath 2: water; triethylamine / 1,4-dioxane / 3 h / 20 °C View Scheme
参考文献
Buesking, Andrew W.; Baguley, Tyler D.; Ellman, Jonathan A.
Organic Letters, 2011 , vol. 13, # 5 p. 964 - 967
反应条件
1: 97 percent / NaI / dimethylformamide / 18 h / Ambient temperature 2: 72 percent / aq. K2CO3 / methanol / 3.5 h 3: NaBH4 / tetrahydrofuran; methanol / 1 h / 0 °C View Scheme
参考文献
Remuzon, Philippe; Dussy, Christian; Jacquet, Jean-Pierre; Roty, Pascale; Bouzard, Daniel
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1181 - 1188
反应条件
1: 72 percent / aq. K2CO3 / methanol / 3.5 h 2: NaBH4 / tetrahydrofuran; methanol / 1 h / 0 °C View Scheme
参考文献
Remuzon, Philippe; Dussy, Christian; Jacquet, Jean-Pierre; Roty, Pascale; Bouzard, Daniel
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1181 - 1188
