2-甲基-2-丙基(3,4-二羟基-1-苯基-2-丁烷基)氨基甲酸酯合成路线 （共 33 条）
反应条件
in methanol T=20°C; 2 h;
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
1: water; sodium tetrahydroborate / ethanol / 1 h / -8 - 5 °C / Inert atmosphere 2: sodium methylate / methanol / 2 h / 20 - 30 °C / Inert atmosphere View Scheme
参考文献
ScinoPharm Singapore PTE, Ltd.
Patent: US2012/220784 A1, 2012 ;
反应条件
1.1: sodium amide / tetrahydrofuran / 2 h / 60 - 70 °C / Industry scale; Inert atmosphere 1.2: 1 h / -5 - 5 °C 2.1: hydrogenchloride; dimethyl sulfoxide / water / 4 h / 20 - 30 °C / Inert atmosphere 2.2: 0 - 10 °C 2.3: 3 h / 0 - 30 °C / Inert atmosphere 3.1: water; sodium tetrahydroborate / ethanol / 1 h / -8 - 5 °C / Inert atmosphere 4.1: sodium methylate / methanol / 2 h / 20 - 30 °C / Inert atmosphere View Scheme
参考文献
ScinoPharm Singapore PTE, Ltd.
Patent: US2012/220784 A1, 2012 ;
反应条件
1.1: hydrogenchloride; dimethyl sulfoxide / water / 4 h / 20 - 30 °C / Inert atmosphere 1.2: 0 - 10 °C 1.3: 3 h / 0 - 30 °C / Inert atmosphere 2.1: water; sodium tetrahydroborate / ethanol / 1 h / -8 - 5 °C / Inert atmosphere 3.1: sodium methylate / methanol / 2 h / 20 - 30 °C / Inert atmosphere View Scheme
参考文献
ScinoPharm Singapore PTE, Ltd.
Patent: US2012/220784 A1, 2012 ;
反应条件
1: 1.) 1-(chlorocarbonyl)-1-methylene acetate, 2.) NaOMe / 1.) CHCl3, 23 deg C, 3 h, 2.) THF, 23 deg C, 4 h 2: 75 percent / propan-2-ol / 2 h / Heating View Scheme
参考文献
Ghosh, Arun K.; Hussain, Khaja Azhar; Fidanze, Steve
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6080 - 6082
反应条件
triphenylphosphine; diethylazodicarboxylate in chloroform Heating;
参考文献
Tetrahedron Letters, , vol. 38, # 19 p. 3483 - 3486
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile T=35°C; pH=6.7;
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
triphenylphosphine; diethylazodicarboxylate in chloroform Heating;
参考文献
Tetrahedron Letters, , vol. 38, # 19 p. 3483 - 3486
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile T=35°C; pH=6.7;
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
potassium permanganate; sodium periodate; sodium carbonate in 1,4-dioxane; water 17 h;
参考文献
Buesking, Andrew W.; Baguley, Tyler D.; Ellman, Jonathan A.
Organic Letters, 2011 , vol. 13, # 5 p. 964 - 967
